The survey of 35 countries found the UK had the third-highest number of 15 and 16-year-olds with an alcohol problem.
Professor Martin Plant, the University of the West of England academic who led the research, said: "The UK retains its unenviable position in relation to both binge-drinking, intoxication and alcohol-related problems among teenagers.
"This problem is both serious and chronic. I hope that the Government will prioritise policies that are effective to reduce heavy drinking and alcohol-related disorder and health problems among young people."
This is the most detailed international study carried out into binge-drinking and drug use among teenagers.
It included a sample of 1,004 boys and 1,175 girls from the UK, who were also found to suffer from high levels of relationship, sexual and delinquency problems.
The survey found that more than half of British teenagers had been binge-drinking in the past month, but girls were more likely to drink to excess than boys.
A statement from the university said: "The fact that some teenage girls are binge-drinking even more than boys suggests that in the UK and elsewhere a profound social change has been taking place.
"It is clearly no longer socially unacceptable for females to drink heavily or to become intoxicated.
"This may reflect factors such as greater female social and economic empowerment and changing social roles as well as the marketing practices of the beverage alcohol industry."
Only youngsters in Bulgaria and the Isle of Man abused drink to a greater extent.
But the report found the number of teenage smokers in the UK had fallen since 1999, whilst only 11% of British teenagers admitted to smoking cannabis in the past month.
Professor Plant added that many teenagers in the UK were developing serious health problems and dying prematurely because of their drinking.
He said: "There is a clear scientific consensus that alcohol education and mass media campaigns have a very poor track record in influencing drinking habits.
"Far more effective – and cost effective – policies include using taxation to make alcohol less affordable.
"Many people whose alcohol consumption is generally moderate also experience some adverse effects from their drinking.
"It is therefore recommended that a minimum price of 50p per unit of alcohol should be introduced. This would save over 3,000 lives per year.
"It would also reduce problems such as absenteeism, public disorder and hospital admissions. This measure would particularly affect harmful and hazardous drinkers.
"It could save £1 billion-per-year in the cost of alcohol-related harm." (Last Updated: 1:40PM GMT 26 Mar 2009)